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How To Play:
The rules are clear: play your piano but don't ever touch the white tiles.
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Features
◈ Many awesome game modes so you never get bored
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◈ Customizable classical piano soundtrack
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◈◈◈ Over 160,000,000 downloads worldwide. ◈◈◈
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We'd love to hear your suggestions and comments! We've got loads of improvements and new features planned, so stay tuned!
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Business Cooperation:
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Cheetah Mobile is the exclusive agent of Don't Tap The White Tile and Just Get 10. We recommend the best games for Cheetah's 800 million users! Contact us:
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Cogan syndrome | |
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Specialty | Rheumatology |
Cogan syndrome is a rare disorder characterized by recurrent inflammation of the front of the eye (the cornea) and often fever, fatigue, and weight loss, episodes of vertigo (dizziness), tinnitus (ringing in the ears) and hearing loss. It can lead to deafness or blindness if untreated. The classic form of the disease was first described by D.G. Cogan in 1945.
Signs and symptoms[edit]
Cogan syndrome is a rare, rheumatic disease characterized by inflammation of the ears and eyes. Cogan syndrome can lead to vision difficulty, hearing loss and dizziness. The condition may also be associated with blood-vessel inflammation (called vasculitis) in other areas of the body that can cause major organ damage in 15% of those afflicted or, in a small number of cases, even death. It most commonly occurs in a person's 20s or 30s. The cause is not known. However, one theory is that it is an autoimmune disorder in which the body's immune system mistakenly attacks tissue in the eye and ear.[1]
Causes[edit]
It is currently thought that Cogan syndrome is an autoimmune disease. The inflammation in the eye and ear are due to the patient's own immune system producing antibodies that attack the inner ear and eye tissue. Autoantibodies can be demonstrated in the blood of some patients, and these antibodies have been shown to attack inner ear tissue in laboratory studies. Infection with the bacteria Chlamydia pneumoniae has been demonstrated in some patients prior to the development of Cogan syndrome, leading some researchers to hypothesize that the autoimmune disease may be initiated by the infection. C. pneumoniae is a common cause of mild pneumonia, and the vast majority of patients who are infected with the bacteria do not develop Cogan syndrome.[2]
Diagnosis[edit]
While the white blood cell count, erythrocyte sedimentation rate, and C-reactive protein tests may be abnormal and there may be abnormally high levels of platelets in the blood or too few red blood cells in the blood, none of these findings is a reliable indicator of the disease. A slit-lamp examination is essential. Recent work has suggested that high-resolution MRI and antibodies to inner ear antigens may be helpful. Cogan syndrome can occur in children, and is particularly difficultto recognize in that situation.[3]
Treatment[edit]
For more severe disease, oral corticosteroids may be necessary to reduce the inflammatory response. When large amounts of steroids are required or if the disease is severe and is not responding to steroid therapy, other immunosuppressive medications often are recommended. These immunosuppressive drugs include methotrexate, cyclophosphamide, cyclosporine or azathioprine. In some cases, combinations of these medicines are prescribed. Occasionally, if the disease has damaged blood vessels in the ear, cochlear implantation may be used to restore some sense of hearing.
Cinnarizine is mainly used to treat nausea and vomiting associated with motion sickness, vertigo, Ménière's disease, or Cogan syndrome.[4] Studies have shown it to produce significant improvement in hearing loss in some patients.[5]
History[edit]
In 1945, the ophthalmologist David Glendenning Cogan (1908–1993) first described the 'nonsyphilitic interstitial keratitis and vestibuloauditory symptoms' that would later bear his name.[6] In 1963, the atypical form of Cogan syndrome, also known as 'Logan Syndrome' was first described.[7]
References[edit]
- ^'Cogan's Syndrome'. Archived from the original on 2008-10-14. Retrieved 2008-11-06.
- ^Timothy C. Hain. 'Cogan's Syndrome'. Archived from the original on May 17, 2008. Retrieved 2008-11-06.
- ^Timothy C. Hain. 'Cogan's syndrome'. Retrieved 2008-11-06.
- ^'Cogan's Syndrome - Treatment'. Retrieved 2008-11-06.[permanent dead link]
- ^Timothy C. Hain: Cogan's SyndromeArchived 2008-05-17 at the Wayback Machine at the American Hearing Research Foundation, Chicago, Illinois 2008.
- ^Cogan, David G. (1945). 'Syndrome of Nonsyphilitic Interstitial Keratitis and Vestibuloauditory Symptoms'. Archives of Ophthalmology. 33 (2): 144–9. doi:10.1001/archopht.1945.00890140064007.
- ^Bennett FM (April 1963). 'Bilateral recurrent episcleritis associated with posterior corneal changes, vestibulo-auditory symptoms and rheumatoid arthritis'. American Journal of Ophthalmology. 55: 815–8. doi:10.1016/0002-9394(63)92451-6. PMID13967466.
Further reading[edit]
- Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS (November 1980). 'Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature'. Medicine. 59 (6): 426–41. doi:10.1097/00005792-198011000-00003. PMID6969345.
- Gluth MB, Baratz KH, Matteson EL, Driscoll CL (April 2006). 'Cogan syndrome: a retrospective review of 60 patients throughout a half century'. Mayo Clinic Proceedings. 81 (4): 483–8. doi:10.4065/81.4.483. PMID16610568.
- Norton EW, Cogan DG (May 1959). 'Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms; a long-term follow-up'. Archives of Ophthalmology. 61 (5): 695–7. doi:10.1001/archopht.1959.00940090697004. PMID13636563.
- Bicknell JM, Holland JV (March 1978). 'Neurologic manifestations of Cogan syndrome'. Neurology. 28 (3): 278–81. doi:10.1212/wnl.28.3.278. PMID305011.
- Casselman JW, Majoor MH, Albers FW (January 1994). 'MR of the inner ear in patients with Cogan syndrome'. American Journal of Neuroradiology. 15 (1): 131–8. PMID8141044.
- Allen NB, Cox CC, Cobo M, et al. (March 1990). 'Use of immunosuppressive agents in the treatment of severe ocular and vascular manifestations of Cogan's syndrome'. The American Journal of Medicine. 88 (3): 296–301. doi:10.1016/0002-9343(90)90157-9. PMID2309745.
- Kundell SP, Ochs HD (July 1980). 'Cogan syndrome in childhood'. The Journal of Pediatrics. 97 (1): 96–8. doi:10.1016/s0022-3476(80)80142-9. PMID7381656.
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